Florence’s eBinders™

The most adopted eISF in clinical research. Florence eBinders digitizes investigator site files and participant binders, eliminating paper based processes with structured regulatory workflows designed for sites.

Sites need a system built around how they actually execute regulatory work.

Site First

Designed around how sites actually execute regulatory work, aligned to your SOPs, staffing models, and daily workflows.

Inspection Readiness

Maintain always on compliance with embedded audit trails, version control, and compliant eSignatures built directly into daily workflows.

Seamless Collaboration

Work with sponsors and monitors in one shared system, eliminating duplicate uploads and manual reconciliation.

Eliminate paper and take control of your regulatory workflows.

See how it works

Regulatory Workflows

Standardize regulatory execution with configurable eISF templates aligned to your SOPs, enabling in system document creation, review, approval, and filing with complete visibility and audit history.

  • Role Based Permissions

  • Document Version Control

  • Complete Audit Trails

  • Part 11 & Annex 11 eSignatures

  • Digital Regulatory Logs

  • Long-term Archiving

System Administration

Leverage intuitive workflows for rapid study setup and activation, enabling effortless digital multi-site study management.

  • Control and standardize eISF templates and naming conventions based on your workflows and SOPs

  • Customize granular access and permissions for your entire study team and external users

  • Create placeholders, due dates and task assignments to keep studies progressing

  • Identify risk areas with advanced reporting and dashboards

Source Management

Sync source with participant binders to collect all participant source data in a single location.

  • Integrate with your CTMS and EMR/EHR system to route certified copies to participant binders

  • Built-in redaction controls ensure only authorized users see Protected Health Information (PHI)

  • Florence ePrinter enables secure, encrypted digital exchange of sensitive documents between clinical systems

Study Oversight and Collaboration

Enable structured collaboration with sponsors and monitors through shared document access, controlled review workflows, and activity tracking that reduce disruption and eliminate duplicate uploads.

  • Pre Visit Document Review

  • Redacted Binder Access

  • Visit Scheduling

  • Monitor Activity Tracking

Real success, real stories

“We love the ability to set up regulatory files just like we would in paper format. Importing is so easy, as is sending out requests for signatures.”

– Mark Sulik, PharmD CCRP, Director of Clinical Research

  • 20-30+ hours saved per week

  • Smooth transition from paper to digital workflows

  • Faster document circulation and signatory capture

  • Reduced signature wait time from over a week to under an hour

  • Accelerated staff onboarding from weeks to days

  • Supports 1,200+ MCW and affiliate users, plus 1,000+ external monitors

  • Enhanced document organization and standardized processes, improving efficiency and reducing duplication across multiple studies

“Operationally, digital collaboration brings about so much improvement it is well worth every dollar that you invest in it.”

– Chad Adams, Associate Director of Research Administration

  • 100% elimination of paper shadow-charts and binder rooms

  • eCRF workflows across reg and clinical teams

  • ePrinter capturing all source data from EMR

Florence is used to support over 7.2 million monitoring workflows per month across 20k sites in 90+ countries.

  • 30 studies onboarded the first week

  • 150+ PIs trained on eSignatures

  • 10,000 eSignatures in the first 6 months

  • OnCore CTMS Integration

  • 41.8% reduction in document cycle time

  • 49.2% acceleration in study startup

  • 12.5% increase in study capacity

  • 6,500 monthly document signatures

  • 580,000+ documents managed in Florence

Integrate with the tools you use every day.

Drive results that matter

Mitigate Risk

Stay inspection-ready with automated audit trails, version control, user permissions, and secure in-app redaction.

Accelerate Timelines

Cut study start-up times by up to 40% and reduce study close-out by two weeks with effortless workflow streamlining.

Increase Capacity

Save 20-30 hours weekly, allowing more focus on patient care and less on administrative tasks.

In clinical research, compliance is crucial. We’ve got you covered globally.

Improve Your Operational Efficiency