Free Product Tour

The Electronic Investigator Site File (eISF) Sites Actually Use

Florence eBinders is the leading eISF, the electronic regulatory binder where sites do their real work, connected to sponsors in real time. Most investigator site files still live in paper binders, email threads, and one-way portals. The result: slow study startup, limited sponsor visibility, and unnecessary compliance risk.

Florence eBinders helps research sites digitize regulatory binders, collaborate with sponsors in real time, and stay inspection-ready.

Take the 5-minute self-guided tour to see how leading research sites:

  • Standardize your eISF and regulatory binder across every study
  • Accelerate study startup and activation
  • Eliminate manual document and signature workflows
  • Enable remote monitoring and collaboration
  • Maintain always-on inspection readiness
  • Gain real-time visibility into site operations

See how it works

Simplify Regulatory Work. Stay Inspection Ready.

Replace paper based regulatory processes with configurable eISF workflows that standardize document creation, review, approvals, filing, version control, and audit history across every study.

  • Role Based Access

  • Version Control

  • Audit Trails

  • Part 11 & Annex 11 eSignatures

  • Digital Logs

  • Long-term Archiving

Standardize Every Study from Day One

Reduce study setup time with centralized administration tools that standardize eISF templates, permissions, task management, reporting, and workflows across every site.

  • Control and standardize eISF templates and naming conventions based on your workflows and SOPs

  • Customize granular access and permissions for your entire study team and external users

  • Create placeholders, due dates and task assignments to keep studies progressing

  • Identify risk areas with advanced reporting and dashboards

Source Documents Without the Manual Work

Eliminate manual document collection with secure integrations, automated source capture, built in PHI protection, and encrypted document exchange between clinical systems.

  • Integrate with your CTMS and EMR/EHR system to route certified copies to participant binders

  • Built-in redaction controls ensure only authorized users see Protected Health Information (PHI)

  • Florence ePrinter enables secure, encrypted digital exchange of sensitive documents between clinical systems

Keep Sites, Sponsors, and Monitors Aligned

Reduce delays and duplicate work with secure document sharing, structured review workflows, visit management, and real time monitoring activity in one shared workspace.

  • Pre Visit Document Review

  • Redacted Binder Access

  • Visit Scheduling

  • Monitor Activity Tracking

Drive results that matter

Mitigate Risk

Stay inspection-ready with automated audit trails, version control, user permissions, and secure in-app redaction.

Accelerate Timelines

Cut study start-up times by up to 50% and reduce study close-out by two weeks with effortless workflow streamlining.

Increase Capacity

Save 20-30 hours weekly, allowing more focus on patient care and less on administrative tasks.

Trusted by Sponsors & CROs, Loved by Sites

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