Florence Workflows > Multi-site Management
Manage Multi-site Trials with Electronic Document and Administrative Workflows
Whether you’re supporting an industry study, grant-funded study, or Investigator Initiated Trial, you can manage multi-site administration and regulatory workflows on a single integrated platform.

More than 10,000 sites in 45 countries trust their
Electronic Investigator Site File workflows to Florence eBinders™.
Why Coordinating Centers Choose Florence for Multi-site Trial Workflows

Link eTMF and eISF
Coordinating centers must manage the full Trial Master File as well as their individual Investigator Site Files. Florence’s integrated workflow platform facilitates seamless data exchange between the two environments.

Choose a Suite of Workflow Solutions
Deploy a full digital and remote workflow platform with Electronic Investigator Site Files, Electronic Participant Binders, Electronic Logs and Electronic Consent.

Experience Ease of Use and Excellent Support
Florence is rated the #1 clinical trial workflow platform for ease of use, ease of setup, and support. All of your sites, including those new to research, benefit from our intuitive workflows. Plus, we support Investigator Initiated Studies with complimentary access to our platform.

Enable Secure External Access
Schedule and enable secure remote access for monitoring and collaboration with external users, including industry sponsors, monitors, IRB users and regulatory agencies.

Use Digital Workflows from Start-up to Close-out
Experience intuitive and fully compliant workflows for start-up, electronic signatures, DOA logs, training logs, AE logs, source collection and monitoring.

Stay Compliant at Scale
Ensure compliance across study sites with automated audit trails, version control, PHI redaction, and advanced permission and access controls.
In clinical research, compliance is crucial. We’ve got you covered.






Multi-site Management Workflows with Florence
Multi-site Management Workflows with Florence
Start Up Sites Remotely
Remotely activate and start up study sites with a complete suite of electronic binder solutions.


Enable 24/7 Continuous Monitoring of Sites
Access all study sites anytime for continuous monitoring.
Improve TMF Timeliness and Completeness
We offer multiple methods of creating and gathering TMF documents as well as advanced dashboards.


Communicate and Collaborate with Sites Remotely
Assign tasks and send compliant communications directly in sites’ eISF workflows.
Quality Control Documents and Sync Them to Your eTMF
Eliminate the need for mailing, emailing, and faxing study documents or using legacy site upload portals by directly integrating your eTMF with your sites’ eISFs.

We are committed to making you and your sites successful.
We are committed to making you and your sites successful.
According to user reviews, Florence is rated the #1 clinical trial workflows platform for ease-of-setup, ease-of-use and customer support.
Why being rated #1 out of 190 clinical trial platforms on G2, the peer-to-peer review site, matters for you.
“The regulatory team is very happy with the process. It gives me great pleasure to have partnered with Florence to help them be more efficient with tasks.”
Director, Research Quality and Regulatory Compliance
Multi-Site Health System
“We have staff in several different locations, so having a central access point for our information was very important and a huge draw.”
Associate Director of Research Administration
Academic Cancer Center
“We manage multi-center studies, and eBinders gives us the power to be several places at once.”
Director of Clinical Research Administration
Site Network
Florence Supports Site Enablement on a Global Scale
Florence now supports workflows between sponsors and more than 10,000 study sites in 45 countries.



We love working with sponsors on Florence. Collaborating in real-time on a single document management platform helps us tackle study tasks faster and keep research on track.
Dr. Christina Brennan
VP of Clinical Research